Emerging drug therapies for preventing spontaneous preterm labor and preterm birth

  title={Emerging drug therapies for preventing spontaneous preterm labor and preterm birth},
  author={Ronald F Lamont and A. Jaggat},
  journal={Expert Opinion on Investigational Drugs},
  pages={337 - 345}
  • R. LamontA. Jaggat
  • Published 16 February 2007
  • Medicine
  • Expert Opinion on Investigational Drugs
Preterm birth (PTB) is the main cause of neonatal mortality and morbidity in the developed world. Historically, the approach for the prevention of PTB has been reactive rather than proactive. With the introduction of new screening tests and a greater emphasis on prevention rather than treatment, a number of new approaches have been introduced that show promise. Progesterone, which is responsible for myometrial quiescence in pregnancy and is used in women with a previous history of PTB, is… 

The choice of a tocolytic for the treatment of preterm labor: a critical evaluation of nifedipine versus atosiban

Atosiban was developed specifically to treat preterm labor, so the cost is higher than nifedipine or ritodrine, but the balance of evidence indicates that atosiban is as effective as nifesiban and more effective than β-agonists and is significantly safer than both.

Periodontal disease and bacterial vaginosis as genetic and environmental markers for the risk of spontaneous preterm labor and preterm birth

  • O. SanuR. Lamont
  • Medicine, Biology
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
  • 2011
Objective. The aim of this study was to review the evidence associating periodontal disease, and bacterial vaginosis with preterm birth, and the link with gene polymorphism, as well as the

Statistical Analysis of Factors Affecting the Weight of Babies at Birth

This research work studied statistically those factors which determine the weight of a baby at birth, including mother’s age, Parity, Method of Delivery and the Sex of the baby which covered all births recorded from January 2009 to December 2013 in Nigeria.

Parameter Identification of Biomechanical Model Using Measured Vibration Response to Walking Generated Excitations with Optimization

Normal birth is defined as when a child is born between 37 and 42 completed weeks of pregnancy. If the child is born before 37 weeks of pregnancy, the birth is considered preterm. The causes of


This work is covered by copyright. Unless the document is being made available under a Creative Commons Licence, you must assume that re-use is limited to personal use and that permission from the

Frühgeburt: pränatale und intrapartale Aspekte

Infektionen, Aktivierung der Inflammationskaskaden, Uberdehnung des Uterus, Fehlbildungen des Uterus, mutterlicher Stress sowie verschiedene Formen der Plazentapathologie sind die Hauptursachen von

Determinants of Under-Five Child Mortality in Iran: A Systematic Review

Effective efforts with emphasis on identifying and managing the determinants of child mortality are essential to improve their health indicators.



New perspectives for the effective treatment of preterm labor.

  • M. Keirse
  • Medicine
    American journal of obstetrics and gynecology
  • 1995

Preterm Birth Is Associated With Increased Risk of Maternal and Neonatal Infection

Both neonatal infection and perinatal mortality were increased in association with chorioamnionitis in both preterm and term pregnancies, supporting suggestions that reproductive tract infection plays a possibly preventable role in the pathogenesis of preterm birth.

Can antibiotics prevent preterm birth—the pro and con debate

  • R. Lamont
  • Medicine
    BJOG : an international journal of obstetrics and gynaecology
  • 2005
Antibiotics used prophylactically for the prevention of preterm birth are more likely to be successful if: they are used in women with abnormal genital tract flora (rather than other risk factors for pre term birth, e.g. low BMI, twins, generic previous pretermBirth); they are use early in pregnancy prior to infection (tissue penetration/inflammation and tissue damage).

Progestogen administration in pregnancy may prevent preterm delivery

  • M. Keirse
  • Medicine
    British journal of obstetrics and gynaecology
  • 1990
This analysis provides no support for the view that 17ahydroxyprogesterone caproate protects against miscarriage, but suggests that it does reduce the occurrence of preterm birth.

A randomised controlled trial of metronidazole for the prevention of preterm birth in women positive for cervicovaginal fetal fibronectin: the PREMET Study

More evidence is required about the role of metronidazole and other antibiotics in women at risk of preterm birth, where there is clinical evidence of BV or other microbiologically pathogenic states, and it is wise to recommend caution in the use of any antibiotics in pregnancy.

Progestational Agents to Prevent Preterm Birth: A Meta-Analysis of Randomized Controlled Trials

The use of progestational agents and 17α-hydroxyprogesterone caproate reduced the incidence of preterm birth and low birth weight newborns.

Polyunsaturated fatty acids and risk of preterm delivery.

Dietary supplementation of Omega-3, in addition to other pharmacological measures (17alpha-hydroxyprogesterone caproate), could be implemented for the secondary and/or tertiary prophylaxis of preterm delivery.

Prevention of recurrent preterm delivery by 17 alpha-hydroxyprogesterone caproate.

BACKGROUND Women who have had a spontaneous preterm delivery are at greatly increased risk for preterm delivery in subsequent pregnancies. The results of several small trials have suggested that 17

Calcium Supplementation In Nulliparous Women For The Prevention Of Pregnancy‐Induced Hypertension, Preeclampsia And Preterm Birth: An Australian Randomized Irial

Calcium supplementation during pregnancy reduced the risk of preeclampsia and preterm birth in this nulliparous population and the available evidence for systematic review of all the randomized trials of calcium supplementation shows benefit in reducing therisk of hypertension and preeClampsia.

Calcium supplementation in nulliparous women for the prevention of pregnancy-induced hypertension, preeclampsia and preterm birth: an Australian randomized trial. FRACOG and the ACT Study Group.

An updated systematic review of the 9 randomized trials of calcium supplementation in pregnancy shows a significant reduction in the risk of hypertension and preeclampsia although no effect on preterm birth.