Emerging complexity of protein ubiquitination in the NF-κB pathway.

  title={Emerging complexity of protein ubiquitination in the NF-κB pathway.},
  author={Hasem Habelhah},
  journal={Genes & cancer},
  volume={1 7},
Members of the nuclear factor-κB (NF-κB) family of transcription factors play critical roles in regulating the expression of genes whose products are involved in inflammation, the immune response, cell proliferation, and the suppression of both death receptor- and stress-induced apoptosis. Abnormal NF-κB activation has been observed in various inflammatory diseases and many types of cancers. Gene knockout studies have clearly demonstrated that most of the physiologically relevant stimuli that… CONTINUE READING

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