Emerging approaches for treatment of schizophrenia: modulation of glutamatergic signaling.

@article{Noetzel2012EmergingAF,
  title={Emerging approaches for treatment of schizophrenia: modulation of glutamatergic signaling.},
  author={Meredith J. Noetzel and Carrie K Jones and P Jeffrey Conn},
  journal={Discovery medicine},
  year={2012},
  volume={14 78},
  pages={335-43}
}
Treatment options for schizophrenia that address all symptom categories (positive, negative, and cognitive) are lacking. Novel compounds that regulate signaling by the major excitatory neurotransmitter in the brain, glutamate, are emerging as a novel approach for the treatment of this disorder. Currently available medications ameliorate positive symptoms but do not have efficacy in reducing negative symptoms or cognitive disturbances. It is possible that agents that target glutamatergic… CONTINUE READING