Emerging applications of recombinant human granulocyte-macrophage colony-stimulating factor.

@article{Armitage1998EmergingAO,
  title={Emerging applications of recombinant human granulocyte-macrophage colony-stimulating factor.},
  author={James Olen Armitage},
  journal={Blood},
  year={1998},
  volume={92 12},
  pages={
          4491-508
        }
}
s of the 34th Interscience Conference on Antimicrobial Agents and Chemotherapy. Orlando, FL. Washington, DC, American Society for Microbiology, 1994, p 266 (abstr H76) 148. Masucci G, Wersäll P, Ragnhammar P, Mellstedt H: Granulocytemonocyte-colony-stimulating factor augments the cytotoxic capacity of lymphocytes and monocytes in antibody dependent cellular cytotoxicity. Cancer Immunol Immunother 29:288, 1989 149. Grabstein KH, Urdal DL, Tushinski RJ, Mochizuki DY, Price VL, Cantrell MA, Gillis… Expand
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References

SHOWING 1-10 OF 189 REFERENCES
Induction of macrophage tumoricidal activity by granulocyte-macrophage colony-stimulating factor.
TLDR
This purified human recombinant GM-CSF stimulated peripheral blood monocytes in vitro to become cytotoxic for the malignant melanoma cell line A375 and stimulated T cell-derived lymphokine, gamma-interferon, to become tumoricidal against this malignant cell line. Expand
Granulocyte-macrophage colony-stimulating factor: pleiotropic cytokine with potential clinical usefulness.
TLDR
Granulocyte-macrophage colony-stimulating factor significantly increased circulating numbers of several myeloid cells and produced dose-dependent toxicity consisting primarily of myalgias, fever, fluid retention, and serosal effusions. Expand
Granulocyte‐macrophage‐colony‐stimulating factor: a review from preclinical development to clinical application
TLDR
RhGM-CSF has been approved as indicated therapy by the Food and Drug Administration for prophylaxis of neutropenic complications in patients undergoing autologous bone marrow transplantation (BMT) for lymphoid malignancy and/or complications related to neutropenia and infection in patients with delayed or failed engraftment after BMT. Expand
Granulocyte-macrophage colony-stimulating factor enhances selective effector functions of tissue-derived macrophages
TLDR
In addition to stimulating macrophage growth, GM-CSF selectively promotes the functional capacity of tissue-derived macrophages, and has no effect onmacrophage anti-Toxoplasma activity or on expression of Iad. Expand
Recombinant granulocyte/macrophage colony-stimulating factor activates macrophages to inhibit Trypanosoma cruzi and release hydrogen peroxide. Comparison with interferon gamma
TLDR
Recombinant granulocyte/macrophage colony-stimulating factors of mouse and human origins activated macrophages of the homologous species to inhibit the replication of the protozoan parasite T. cruzi, but r Mu-GM-CSF was less potent and less effective than rMu-IFN-gamma in the tests used. Expand
Recombinant human granulocyte-macrophage colony-stimulating factor in patients with advanced malignancy: a phase Ib trial.
We evaluated the toxic, hematopoietic, and immunomodulatory effects of recombinant human granulocyte-macrophage colony-stimulating factor (rHuGM-CSF). The rHuGM-CSF was administered at doses up to 50Expand
Granulocyte-macrophage colony-stimulating factor: an effective adjuvant for protein and peptide-based vaccines.
TLDR
Granulocyte-macrophage colony-stimulating factor was as effective as CFA in generating rat neu specific DTH responses after immunization with a neu peptide based vaccine, whereas peptides alone were non-immunogenic. Expand
Enhancement of human eosinophil cytotoxicity and leukotriene synthesis by biosynthetic (recombinant) granulocyte-macrophage colony-stimulating factor.
TLDR
Pro purified biosynthetic (recombinant) human T lymphocyte granulocyte-macrophage colony-stimulating factor (GM-CSF) enhanced markedly two eosinophil functions: cytotoxicity toward schistosomula and calcium ionophore A23187-induced generation of leukotriene C4 (LTC4) by a mean of 135%. Expand
Granulocyte-macrophage colony-stimulating factor augments the primary antibody response by enhancing the function of antigen-presenting cells.
TLDR
The role that GM-CSF plays in augmenting immune responses may not be solely accounted for by its ability to cause the proliferation or differentiation of macrophages, but more than likely includes its able to enhance the function of antigen-presenting macrophaging. Expand
Activation of lymphocytes induced by recombinant human granulocyte-macrophage colony-stimulating factor in patients with malignant lymphoma.
TLDR
Investigation of effects of recombinant human granulocyte-macrophage colony-stimulating factor on lymphoid cells in vivo provides evidence that administration of rhGM-CSF might activate lymphocytes in vivo and the impact on the remission rate and duration, as well as survival in patients with NHL, warrants further investigation. Expand
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