Emerging Themes in Regulation of Global mRNA Turnover in cis.

  title={Emerging Themes in Regulation of Global mRNA Turnover in cis.},
  author={C A Chen and A B Shyu},
  journal={Trends in biochemical sciences},
  volume={42 1},
mRNA is the molecule that conveys genetic information from DNA to the translation apparatus. mRNAs in all organisms display a wide range of stability, and mechanisms have evolved to selectively and differentially regulate individual mRNA stability in response to intracellular and extracellular cues. In recent years, three seemingly distinct aspects of RNA biology-mRNA N6-methyladenosine (m6A) modification, alternative 3' end processing and polyadenylation (APA), and mRNA codon usage-have been… CONTINUE READING
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