Emerging Role of Endosomal Toll-Like Receptors in Rheumatoid Arthritis

@inproceedings{Thwaites2014EmergingRO,
  title={Emerging Role of Endosomal Toll-Like Receptors in Rheumatoid Arthritis},
  author={Ryan Thwaites and Giselle Chamberlain and Sandra M. Sacre},
  booktitle={Front. Immunol.},
  year={2014}
}
Toll-like receptors (TLRs) and their downstream signaling pathways have been comprehensively characterized in innate immunity. In addition to this function, these receptors have also been suggested to be involved in the pathogenesis of many autoimmune diseases, including rheumatoid arthritis (RA). Murine in vivo models and human in vitro tissue models of RA have provided a wealth of information on the potential activity of TLRs and components of the downstream signaling pathways. Whilst most… CONTINUE READING
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