Emerging Proteomic Technologies Provide Enormous and Underutilized Potential for Brain Cancer Research

@article{Tian2015EmergingPT,
  title={Emerging Proteomic Technologies Provide Enormous and Underutilized Potential for Brain Cancer Research},
  author={Qiang Tian and Vineet Sangar and Nathan D. Price},
  journal={Molecular \& Cellular Proteomics},
  year={2015},
  volume={15},
  pages={362 - 367}
}
High-throughput technologies present immense opportunities to characterize brain cancer biology at a systems level. However, proteomic studies of brain cancers are still relatively scarce. Here we discuss the latest proteomic technologies, their application to profiling and quantitation of brain proteomes and how we expect these technologies will be applied to study brain cancer proteomes in the future. Mass spectrometry based proteomics with increased specificity, coverage and throughput will… 

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References

SHOWING 1-10 OF 40 REFERENCES

Evolution of Translational Omics: Lessons Learned and the Path Forward

Challenges in transforming the great promise of new technologies into clinical laboratory tests that can help patients directly has happened more slowly than anticipated, and these challenges converged during a recent case involving premature use of omics-based tests in clinical trials at Duke University.

Identification of novel biomarkers of brain damage in patients with hemorrhagic stroke by integrating bioinformatics and mass spectrometry-based proteomics.

Novel biomarkers of brain injury (α-Inx, NFM, and β-Syn) were identified in the CSF of patients with HS and Investigating the role of these proteins in blood with more sensitive methods is warranted.

Phosphoproteome of Human Glioblastoma Initiating Cells Reveals Novel Signaling Regulators Encoded by the Transcriptome

An in-depth phosphoproteome analysis led to identification of novel phosphorylated molecules encoded by the undefined sequence regions of the human transcripts, one of which was regulated upon external stimulation in human glioblastoma initiating cells.

SWATH analysis of the synaptic proteome in Alzheimer's disease

Molecular signatures from omics data: From chaos to consensus

This paper discusses the process of molecular signature discovery on the basis of omics data, and highlights potential pitfalls in the discovery process, as well as strategies that can be used to increase the odds of successful discovery.

Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma

The genome sequence of single cells isolated from brain glioblastomas was examined, which revealed shared chromosomal changes but also extensive transcription variation, including genes related to signaling, which represent potential therapeutic targets.

Proteomics Analysis of Cancer Exosomes Using a Novel Modified Aptamer-based Array (SOMAscanTM) Platform*

Over 300 proteins of hitherto unknown association with prostate cancer exosomes are described and it is suggested that the SOMAmer®-based assay technology is an effective proteomics platform for exosome-associated biomarker discovery in diverse clinical settings.

A Blood-Based Proteomic Classifier for the Molecular Characterization of Pulmonary Nodules

A panel of 13 proteins was discovered that was able to distinguish benign lung nodules from early-stage lung cancers in a clinical study and validated in a second clinical study with new patients, providing insightful information on the disease status of lung nodule beyond the clinical risk factors currently used by physicians.

Proteomic analysis of post mortem brain tissue from autism patients: evidence for opposite changes in prefrontal cortex and cerebellum in synaptic connectivity-related proteins

These findings suggest altered structural and/or functional connectivity in the prefrontal cortex and cerebellum in autism patients, as shown by opposite effects on proteins involved in myelination and synaptic function.