Emerging H5N8 avian influenza viruses

  title={Emerging H5N8 avian influenza viruses},
  author={Wei-feng Shi and George Fu Gao},
  pages={784 - 786}
The global spread of H5N8 avian influenza viruses is a public health concern The first confirmed outbreak of highly pathogenic avian influenza virus (HPAIV) in birds was documented in Scotland in 1959 with the influenza A H5N1 subtype, although there have been numerous suspected HPAIV outbreaks documented globally since 1878. H5N1 and its genetic reassortants (including H5N2, H5N5, H5N6, and H5N8) have been found to cause thousands of outbreaks worldwide (1, 2) in both farmed poultry and wild… 

Unignorable public health risk of avian influenza virus during COVID‐19 pandemic

The elevated trend of human infections with the emerging AIV during ongoing COVID-19 circulation still highlights the alert of the possible risk for the next human pandemic3.

Genetic Characterization of Highly Pathogenic Avian Influenza A(H5N8) Virus in Pakistani Live Bird Markets Reveals Rapid Diversification of Clade Viruses

There is a need for systematic avian influenza surveillance in live bird markets in Pakistan to monitor for potential A(H5Nx) variants that may arise from poultry populations, including mutations associated with increased haemagglutinin affinity to human α-2,6 receptors.

Re-emergence of H5N8 highly pathogenic avian influenza virus in wild birds, China

The genetic characterizations and phylogenetic relationships of four clade 2.3.4b H5N8 highly avian influenza viruses identified from a sick whooper swan and environmental samples collected in the Yellow River Reservoir Area in late November 2020 suggest these isolates might be imported into China via migratory birds.

Emergence, Evolution, and Biological Characteristics of H10N4 and H10N8 Avian Influenza Viruses in Migratory Wild Birds Detected in Eastern China in 2020

The North American H10 viruses have been successfully introduced to Asia by migratory birds and further reassorted with other subtypes to generate novel H10N4 and H10n8 viruses in eastern China.

Divergent Reassortment and Transmission Dynamics of Highly Pathogenic Avian Influenza A(H5N8) Virus in Birds of China During 2021

It is found that Korea is the main output geographic location in the spread of these H5N8 viruses to northern and eastern China, and especially, the co-circulation of H5n8 viruses occurred within China, with central China acted as a seeding population during the H 5N8 epidemic.

Five Independent Cases of Human Infection with Avian Influenza H5N6 — Sichuan Province, China, 2021

The genomic analysis of the H5N6 genomes showed the features of AIV genomic reassortments and key residue substitutions, demonstrating a risk of the persistence and evolution of the virus to trigger sporadic outbreaks and even pandemics, which need continuous surveillance.

Influenza A Viruses and Zoonotic Events—Are We Creating Our Own Reservoirs?

To reduce zoonotic events, it is important to control the spread of IAV within these animal reservoirs, for example with efficient vaccination strategies, but also to critically surveil the different manmade reservoirs to evaluate the emergence of new IAV strains with pandemic potential.

The arrival of highly pathogenic avian influenza viruses H5N8 in Iran through two windows, 2016

It seems that the introduction of these H5N8 HPAI strains in Iran probably occurred through the West Asia–East African flyway by wild migratory aquatic birds.

Peering into Avian Influenza A(H5N8) for a Framework towards Pandemic Preparedness

To be better prepared against H5N8 and other influenza A viruses, mutational and reassortment libraries can potentially be built, allowing them to be tested on various models complemented with deep-sequencing and automation.

Poultry to Human Passport: Cross-species Transmission of Zoonotic H7N9 Avian Influenza Virus to Humans

Although zoonoses of H7N9 and other subtypes of avian influenza viral infections remain rare, the virus could acquire sufficient mammalian adaptive mutations to allow it to cause a future influenza pandemic.



Pandemic potential of highly pathogenic avian influenza clade A(H5) viruses

An assessment of the likelihood of clade A(H5) viruses gaining human‐to‐human transmissibility and impact on human health should such human-to-human transmission occur.

Re-Invasion of H5N8 High Pathogenicity Avian Influenza Virus Clade in Hokkaido, Japan, 2020

Data imply that HPAI virus clade should have been delivered by bird migration despite the intercontinental distance, although it was not defined whether NP/Hok/20 was transported from Europe via Siberia where migratory birds nest in the summer season.

Outbreaks of Highly Pathogenic Avian Influenza (H5N6) Virus Subclade in Swans, Xinjiang, Western China, 2020

In January 2020, the subclade of highly pathogenic avian influenza (H5N6) virus infected migratory whooper swans and mute swans in Xinjiang, western China. The virus is lethal to chickens

World Organisation for Animal Health (OIE)

The World Organisation for Animal Health is responsible for improving animal health and welfare worldwide. Created in 1924 as the “Office International des Epizooties” of which it has kept its

World Health Organization

The data and methods used to produce the Version 2 estimates of burden of hypertensive disorders of pregnancy for the year 2000 are summarized and the long-term sequelae of both preeclampsia or eClampsia are not well evaluated.

Evolution of the Asian H5 hemagglutinin

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Human infection with avian influenza A (H5N8) -the Russian Federation

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Cumulative number of confirmed human cases for avian influenza A(H5N1) reported to WHO

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The Global Consortium for H5N8 and Related Influenza Viruses

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