Emerging Area of Aging Research: Long‐Lived Animals with “Negligible Senescence”

@article{Guerin2004EmergingAO,
  title={Emerging Area of Aging Research: Long‐Lived Animals with “Negligible Senescence”},
  author={J. C. Guerin},
  journal={Annals of the New York Academy of Sciences},
  year={2004},
  volume={1019}
}
  • J. Guerin
  • Published 2004
  • Biology, Medicine
  • Annals of the New York Academy of Sciences
Abstract: Field observations have suggested for quite some time that certain fish, turtles, and invertebrates have extremely long maximum life span potential. Age validation techniques have since confirmed these observations, but scientific analysis to understand the genetic and biochemical basis of this longevity has occurred only recently. The Centenarian Species and Rockfish Project now encompasses 13 pilot research projects, including such diverse investigations as histology, a cDNA library… Expand

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References

SHOWING 1-10 OF 10 REFERENCES
History and prospects: symposium on organisms with slow aging
TLDR
It is pointed out that organisms with these vastly different life spans have essentially identical cells within an evolutionary group and that the cellular tool kit that existed by 600 million years ago allowed the evolution of life spans ranging up to one million-fold difference in length. Expand
Longevity, senescence, and the genome
TLDR
By comparing species that have different developmental and life spans, Finch proposes a typology of senescence from rapid to gradual to negligible, and he provides the first multiphyletic calculations of mortality rate constants. Expand
Ageing in reptiles.
TLDR
Findings in a few species of lizards and snakes showing gradual senescence support the concept of commonalities in ageing phenomena in vertebrates and it is likely that there are multiple mechanisms ofsenescence in reptiles. Expand
Age determination and validation studies of marine fishes: do deep-dwellers live longer?
TLDR
The analysis of scorpaenids indicates that longevity increases exponentially with maximum depth of occurrence, and radiometric age validation results are presented for four species of Scorpaenid fishes. Expand
210Pb/226Ra determination of longevity in redfish
TLDR
A radiochemical assay of the otolith core was used to confirm the interpretation of annuli in Atlantic redfish, Sebastes mentella, to at least an age of 65 yr, and it appears that redfish live to a age of at least 75 yrs in the waters off of Nova Scotia. Expand
Nutritional Ecology of Sea Turtles
TLDR
Comparison with green turtles on high-quality, pelleted diets shows that the productivity of wild populations is well below their genetic potential, and Ironically, nutrient limitation acting through delayed sexual maturity may benefit green turtles during periods of intense exploitation by man. Expand
Confirmation of longevity in Sebastes diploproa (Pisces: Scorpaenidae) from 210Pb/226Ra measurements in otoliths
TLDR
Estimates of longevity in the genus Sebastes near 80 yr are confirmed because the magnitude of the 210Pb/226Ra radioactive disequilibrium in each otolith group, when compared to the number of growth-Zones and the otolith weight histories derived with the two techniques, identifies the growth-zones revealed by otolith sections as annual features. Expand
Age and growth estimates of bowhead whales (Balaena mysticetus) via aspartic acid racemization
TLDR
A total of 48 eye globes were collected and analyzed to estimate ages of bowhead whales using the aspartic acid racemization technique, and growth appears faster for females than males, and age at sexual maturity occurs at around 25 years of age. Expand