• Corpus ID: 238856783

Emergent properties of collective gene expression patterns in multicellular systems

  title={Emergent properties of collective gene expression patterns in multicellular systems},
  author={Matthew Smart and Anton Zilman},
Multicellular organisms are composed of a wide range of stable tissues containing different cell types. It remains unclear how a large number of interacting cells can precisely coordinate their gene expression during tissue self-organization. Here we develop a spin glass model of tissue gene expression which accounts for intracellular and intercellular gene regulation. The model provides a theoretical framework for tissue selforganization, with stable tissue configurations corresponding to… 

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