Emergent decarboxylase activity and attenuation of α/β-hydrolase activity during the evolution of methylketone biosynthesis in tomato.

@article{Auldridge2012EmergentDA,
  title={Emergent decarboxylase activity and attenuation of α/β-hydrolase activity during the evolution of methylketone biosynthesis in tomato.},
  author={Michele E. Auldridge and Yongxia Guo and Michael B Austin and Justin Ramsey and Eyal Fridman and Eran Pichersky and Joseph P Noel},
  journal={The Plant cell},
  year={2012},
  volume={24 4},
  pages={1596-607}
}
Specialized methylketone-containing metabolites accumulate in certain plants, in particular wild tomatoes in which they serve as toxic compounds against chewing insects. In Solanum habrochaites f. glabratum, methylketone biosynthesis occurs in the plastids of glandular trichomes and begins with intermediates of de novo fatty acid synthesis. These fatty-acyl intermediates are converted via sequential reactions catalyzed by Methylketone Synthase2 (MKS2) and MKS1 to produce the n-1 methylketone… CONTINUE READING

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