Emergency oral anticoagulant reversal: the relative efficacy of infusions of fresh frozen plasma and clotting factor concentrate on correction of the coagulopathy.

@article{Makris1997EmergencyOA,
  title={Emergency oral anticoagulant reversal: the relative efficacy of infusions of fresh frozen plasma and clotting factor concentrate on correction of the coagulopathy.},
  author={Michael Makris and Michael Greaves and Wendy Shapera Phillips and Steve Kitchen and Frits R Rosendaal and Elizabeth F. Preston},
  journal={Thrombosis and haemostasis},
  year={1997},
  volume={77 3},
  pages={477-80}
}
Haemorrhage, including intracranial bleeding, is a common, potentially lethal complication of warfarin therapy and rapid and complete reversal of anticoagulation may be life-saving. Fresh frozen plasma (FFP) and vitamin K are most frequently administered. Because of the variable content of vitamin K-dependent clotting factors in FFP, and the effects of dilution, the efficacy of this approach is open to doubt. We have therefore compared the effects of FFP and clotting factor concentrates on the… CONTINUE READING
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