Emergence of vancomycin tolerance in Streptococcus pneumoniae

@article{Novak1999EmergenceOV,
  title={Emergence of vancomycin tolerance in Streptococcus pneumoniae},
  author={R. Novak and B. Henriques and E. Charpentier and S. Normark and E. Tuomanen},
  journal={Nature},
  year={1999},
  volume={399},
  pages={590-593}
}
Streptococcus pneumoniae, the pneumococcus, is the most common cause of sepsis and meningitis. Multiple-antibiotic-resistant strains are widespread, and vancomycin is the antibiotic of last resort,. Emergence of vancomycin resistance in this community-acquired bacterium would be catastrophic. Antibiotic tolerance, the ability of bacteria to survive but not grow in the presence of antibiotics, is a precursor phenotype to resistance. Here we show that loss of function of the VncS histidine kinase… Expand
340 Citations
Clinical isolates of Streptococcus pneumoniae that exhibit tolerance of vancomycin.
  • 101
  • PDF
Vancomycin tolerance in Gram-positive cocci.
  • 17
  • Highly Influenced
Resistance mechanisms of gram-positive bacteria.
  • B. Berger-Bächi
  • Biology, Medicine
  • International journal of medical microbiology : IJMM
  • 2002
  • 99
Antibiotic tolerance in pneumococci.
  • B. Henriques Normark, S. Normark
  • Biology, Medicine
  • Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
  • 2002
  • 44
Vancomycin-tolerant Streptococcus pneumoniae and its clinical significance.
  • 13
Mechanisms of antibiotic resistance and tolerance in Streptococcus pneumoniae.
  • 66
Molecular analysis of antibiotic tolerance in pneumococci.
  • 10
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 25 REFERENCES
Penicillin tolerance in multiply drug-resistant natural isolates of Streptococcus pneumoniae.
  • 98
Microbiological and clinical significance of a new property of defective lysis in clinical strains of pneumococci.
  • 64
  • PDF
Genetic identification of exported proteins in Streptococcus pneumoniae
  • 96
...
1
2
3
...