Emergence of uterine pathology during accelerated biological aging in FSH receptor-haploinsufficient mice.

@article{Danilovich2002EmergenceOU,
  title={Emergence of uterine pathology during accelerated biological aging in FSH receptor-haploinsufficient mice.},
  author={Natalia Danilovich and Indrojit Roy and M. Ram Sairam},
  journal={Endocrinology},
  year={2002},
  volume={143 9},
  pages={
          3618-27
        }
}
A fully functional FSH receptor (Fshr) is required for ovarian follicular development and fertility. Fshr null females are sterile because of failure of follicular maturation, ovulation, and estrogen deficiency. Because Fshr-haploinsufficient females also begin to show age-dependent reproductive deficits that mimic biological aging, we have investigated the changes that occur in the uterus of these mice. The uterine weight in 12-month-old Fshr +/- mice increased 2-fold, and most retired… CONTINUE READING
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