Emergence of therapy-unrelated CML on a background of BCR-ABL-negative JAK2V617F-positive chronic idiopathic myelofibrosis.

@article{Jallades2008EmergenceOT,
  title={Emergence of therapy-unrelated CML on a background of BCR-ABL-negative JAK2V617F-positive chronic idiopathic myelofibrosis.},
  author={Laurent Jallades and Sandrine Hayette and Isabelle Tigaud and Anna Johnston and Bertrand Coiffier and J Magaud and Martine Ffrench},
  journal={Leukemia research},
  year={2008},
  volume={32 10},
  pages={1608-10}
}
We report the emergence of a chronic myeloid leukaemia (CML) during the course of a JAK2V617F-positive chronic idiopathic myelofibrosis (CIMF) in the absence of any myelosuppressive treatment. Although a response to imatinib was observed, the underlying myelofibrosis persisted after treatment and hydroxyurea was finally added to control the persistent thrombocytosis. Such rare patients with co-existing BCR-ABL translocation and JAK2V617F mutation must be identified in view of the possibility of… CONTINUE READING
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