Emergence of the silicon human and network targeting drugs.

@article{Kolodkin2012EmergenceOT,
  title={Emergence of the silicon human and network targeting drugs.},
  author={Alexey Kolodkin and Fred C. Boogerd and Nick D Plant and Frank J. Bruggeman and Valeri Goncharuk and Jeantine Lunshof and Rafael Moreno-S{\'a}nchez and Nilgun Yilmaz and Barbara M. Bakker and Jacky L. Snoep and Rudi Balling and Hans V. Westerhoff},
  journal={European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences},
  year={2012},
  volume={46 4},
  pages={190-7}
}
The development of disease may be characterized as a pathological shift of homeostasis; the main goal of contemporary drug treatment is, therefore, to return the pathological homeostasis back to the normal physiological range. From the view point of systems biology, homeostasis emerges from the interactions within the network of biomolecules (e.g. DNA, mRNA, proteins), and, hence, understanding how drugs impact upon the entire network should improve their efficacy at returning the network (body… CONTINUE READING

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