Emergence of the pre-Bötzinger respiratory rhythm generator in the mouse embryo.

  title={Emergence of the pre-B{\"o}tzinger respiratory rhythm generator in the mouse embryo.},
  author={Muriel Thoby-Brisson and J Trinh and Jean Champagnat and Gilles Fortin},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={25 17},
To obtain insights into the emergence of rhythmogenic circuits supporting respiration, we monitored spontaneous activities in isolated brainstem and medullary transverse slice preparations of mouse embryos, combining electrophysiological and calcium imaging techniques. At embryonic day 15 (E15), in a restricted region ventral to the nucleus ambiguus, we observed the onset of a sustained high-frequency (HF) respiratory-like activity in addition to a preexisting low-frequency activity having a… CONTINUE READING
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