Emergence of sigh rhythmogenesis in the embryonic mouse.

  title={Emergence of sigh rhythmogenesis in the embryonic mouse.},
  author={Coralie Chapuis and Sandra Autran and Gilles Fortin and John Simmers and Muriel Thoby-Brisson},
  journal={The Journal of physiology},
  volume={592 10},
In mammals, eupnoeic breathing is periodically interrupted by spontaneous augmented breaths (sighs) that include a larger-amplitude inspiratory effort, typically followed by a post-sigh apnoea. Previous in vitro studies in newborn rodents have demonstrated that the respiratory oscillator of the pre-Bötzinger complex (preBötC) can generate the distinct inspiratory motor patterns for both eupnoea- and sigh-related behaviour. During mouse embryonic development, the preBötC begins to generate… CONTINUE READING
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