Emergence of resistance mutations preceding virologic failure in patients receiving antiretroviral therapy.

@article{Diaz2008EmergenceOR,
  title={Emergence of resistance mutations preceding virologic failure in patients receiving antiretroviral therapy.},
  author={Ricardo Sobhie Diaz and Conceiç{\~a}o A Accetturi and Maria Cec{\'i}lia Araripe Sucupira},
  journal={Journal of acquired immune deficiency syndromes},
  year={2008},
  volume={49 1},
  pages={111-3}
}
To the Editor: The wide use of highly active antiretroviral therapy (HAART) based on HIV-1 protease inhibitors (PIs) has resulted in a steady decline in the incidence of Kaposi sarcoma (KS) and tumor regression in individual cases. Conversely, nonnucleoside reverse transcriptase inhibitor (NNRTI)–based HAART regimens have been implicated in KS relapse. In this cross-sectional study, the risk of switching from PIs to NNRTIs in patients with an ongoing or past history of KS has been… CONTINUE READING

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