Emergence of protease inhibitor resistance mutations in human immunodeficiency virus type 1 isolates from patients and rapid screening procedure for their detection.

@article{Vasudevachari1996EmergenceOP,
  title={Emergence of protease inhibitor resistance mutations in human immunodeficiency virus type 1 isolates from patients and rapid screening procedure for their detection.},
  author={Malamachanahalli B. Vasudevachari and Yuan Zhang and Hiromi Imamichi and Tomozumi Imamichi and Judith Falloon and N. P. Salzman},
  journal={Antimicrobial agents and chemotherapy},
  year={1996},
  volume={40 11},
  pages={2535-41}
}
Patient human immunodeficiency virus type 1 (HIV-1) isolates that are resistant to protease inhibitors may contain amino acid substitutions L10I/V, M46L/I, G-48V, L63P, V82A/F/T, I84V, and L90M in the protease gene. Substitutions at positions 82 and/or 90 occur in variants that display high levels of resistance to certain protease inhibitors. Nucleotide substitutions at these two sites also lead to the loss of two HindII restriction enzyme digestion sites, and these changes make possible a… CONTINUE READING