Emergence of plasmid-mediated colistin resistance (MCR-1) among Escherichia coli isolated from South African patients.

@article{Coetzee2016EmergenceOP,
  title={Emergence of plasmid-mediated colistin resistance (MCR-1) among Escherichia coli isolated from South African patients.},
  author={Jennifer Coetzee and C. Corcoran and Elizabeth Prentice and Mischka Moodley and Marc Mendelson and Laurent Poirel and Patrice L. Nordmann and Adrian John Brink},
  journal={South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde},
  year={2016},
  volume={106 5},
  pages={35-6}
}
The polymyxin antibiotic colistin is an antibiotic of last resort for the treatment of extensively drug-resistant Gram-negative bacteria, including carbapenemase-producing Enterobacteriaceae. The State of the World's Antibiotics report in 2015 highlighted South Africa (SA)'s increasing incidence of these 'superbugs' (3.2% of Klebsiella pneumoniae reported from SA were carbapenemase producers), and in doing so, underscored SA's increasing reliance on colistin as a last line of defence. Colistin… CONTINUE READING
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