Emergence of oxacillinase-mediated resistance to imipenem in Klebsiella pneumoniae.

  title={Emergence of oxacillinase-mediated resistance to imipenem in Klebsiella pneumoniae.},
  author={Laurent Poirel and Claire H{\'e}ritier and Venus Tol{\"u}n and Patrice L. Nordmann},
  journal={Antimicrobial agents and chemotherapy},
  volume={48 1},
Klebsiella pneumoniae strain 11978 was isolated in Turkey in 2001 and was found to be resistant to all beta-lactams, including carbapenems. Cloning and expression in Escherichia coli identified five beta-lactamases, including two novel oxacillinases. The beta-lactamase OXA-48 hydrolyzed imipenem at a high level and was remotely related (less than 46% amino acid identity) to the other oxacillinases. It hydrolyzed penicillins and imipenem but not expanded-spectrum cephalosporins. The bla(OXA-48… CONTINUE READING
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