Emergence of organized bursting in clusters of pancreatic beta-cells by channel sharing.

@article{Sherman1988EmergenceOO,
  title={Emergence of organized bursting in clusters of pancreatic beta-cells by channel sharing.},
  author={Arthur S Sherman and John Rinzel and Joel E. Keizer},
  journal={Biophysical journal},
  year={1988},
  volume={54 3},
  pages={
          411-25
        }
}
Pancreatic beta-cells in an intact Islet of Langerhans exhibit bursting electrical behavior. The Chay-Keizer model describes this using a calcium-activated potassium (K-Ca) channel, but cannot account for the irregular spiking of isolated beta-cells. Atwater I., L. Rosario, and E. Rojas, Cell Calcium. 4:451-461, proposed that the K-Ca channels, which are rarely open, are shared by several cells. This suggests that the chaotic behavior of isolated cells is stochastic. We have revised the Chay… CONTINUE READING

Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 113 CITATIONS, ESTIMATED 91% COVERAGE

Network Complexity and Synchronous Behavior - an Experimental Approach

  • Int. J. Neural Syst.
  • 2010
VIEW 7 EXCERPTS
CITES METHODS & BACKGROUND
HIGHLY INFLUENCED

The electrophysiology of the beta-cell based on single transmembrane protein characteristics.

  • Biophysical journal
  • 2007
VIEW 9 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

Bifurcation structure of a model of bursting pancreatic cells.

VIEW 6 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

Significance of Na/Ca exchange for Ca2+ buffering and electrical activity in mouse pancreatic beta-cells.

  • Biophysical journal
  • 1999
VIEW 7 EXCERPTS
CITES METHODS & BACKGROUND
HIGHLY INFLUENCED

Analysis of a Class of Models of Bursting Electrical Activity in Pancreatic Beta-Cells

  • SIAM Journal of Applied Mathematics
  • 1998
VIEW 10 EXCERPTS
CITES METHODS & BACKGROUND
HIGHLY INFLUENCED

Shaping bursting by electrical coupling and noise

  • Biological Cybernetics
  • 2012
VIEW 7 EXCERPTS
CITES RESULTS, BACKGROUND & METHODS
HIGHLY INFLUENCED

Structure of cell networks critically determines oscillation regularity.

  • Journal of theoretical biology
  • 2012
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

1990
2019

CITATION STATISTICS

  • 16 Highly Influenced Citations