Emergence of oligoclonal T cell populations following therapeutic T cell depletion in rheumatoid arthritis.

@article{Jendro1995EmergenceOO,
  title={Emergence of oligoclonal T cell populations following therapeutic T cell depletion in rheumatoid arthritis.},
  author={Michael C. Jendro and Tom M. Ganten and Eric L Matteson and Cornelia M Weyand and J{\"o}rg J Goronzy},
  journal={Arthritis and rheumatism},
  year={1995},
  volume={38 9},
  pages={1242-51}
}
OBJECTIVE To examine the compartment of CD4+ T cells in patients with rheumatoid arthritis (RA) who have developed persistent lymphopenia following antibody-mediated T cell depletion and to investigate why T cell depletion is of limited therapeutic efficacy. METHODS Circulating T lymphocytes from 10 patients with seropositive RA treated with the monoclonal antibody (MAb) CAMPATH-1H were longitudinally monitored by fluorescence-activated cell sorter analysis with MAb. To assess the molecular… CONTINUE READING

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