Emergence of new clonal abnormalities following interferon-alpha induced complete cytogenetic response in patients with chronic myeloid leukemia: report of three cases

@article{Fayad1997EmergenceON,
  title={Emergence of new clonal abnormalities following interferon-alpha induced complete cytogenetic response in patients with chronic myeloid leukemia: report of three cases},
  author={Luis E. Fayad and H M Kantarjian and SM O’Brien and David C. Seong and Maher Albitar and M Y Keating and Moshe Talpaz},
  journal={Leukemia},
  year={1997},
  volume={11},
  pages={767-774}
}
New treatments which may change the course of a disease, or which have potential carcinogenicity, may result in the development of new cytogenetic or clinical disorders. Three patients with Philadelphia chromosome-positive (Ph-positive) chronic myeloid leukemia (CML) who developed new cytogenetic abnormalities after achieving a cytogenetic complete remission (CR) of their Ph-positive disease with interferon alpha (IFN-alpha) based therapy are described. Patient 1 developed chromosomal… CONTINUE READING