Emergence of neoplastic transformants spontaneously or after exposure to N-methyl-N'-nitro-N-nitrosoguanidine in populations of rat liver epithelial cells cultured under selective and nonselective conditions.

@article{Lee1989EmergenceON,
  title={Emergence of neoplastic transformants spontaneously or after exposure to N-methyl-N'-nitro-N-nitrosoguanidine in populations of rat liver epithelial cells cultured under selective and nonselective conditions.},
  author={Lin W Lee and Ming Sound Tsao and Joe W. Grisham and Garry John Smith},
  journal={The American journal of pathology},
  year={1989},
  volume={135 1},
  pages={63-71}
}
Many studies have shown that cultured rat liver epithelial cells can be neoplastically transformed by repeated or long-continued exposure to chemical carcinogens. These cells also may transform spontaneously in the absence of carcinogen treatment after long-term, continuous passage in culture or after chronic maintenance in a confluent state in vitro. In this study, we have compared the times of emergence and rates of accumulation of transformed cells in populations of rat hepatic epithelial… CONTINUE READING

From This Paper

Topics from this paper.
16 Citations
0 References
Similar Papers

Similar Papers

Loading similar papers…