Emergence of myeloid cells from cultures of J2E erythroid cells is linked with karyotypic abnormalities.

@article{Keil1995EmergenceOM,
  title={Emergence of myeloid cells from cultures of J2E erythroid cells is linked with karyotypic abnormalities.},
  author={U Keil and Samantha J. Busfield and T J Farr and John Papadimitriou and Andrew R. Green and C. G. Begley and S. Peter Klinken},
  journal={Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research},
  year={1995},
  volume={6 4},
  pages={439-48}
}
J2E cells are an erythroid cell line immortalized at the proerythroblast stage of differentiation by the J2 retrovirus which contains the raf and myc oncogenes. In response to erythropoietin, these cells terminally differentiate into mature, hemoglobin-producing erythroid cells. We have shown previously that B cells overexpressing raf and myc acquired the… CONTINUE READING