Emergence of early alterations in network oscillations and functional connectivity in a tau seeding mouse model of Alzheimer’s disease pathology

@inproceedings{Ahnaou2017EmergenceOE,
  title={Emergence of early alterations in network oscillations and functional connectivity in a tau seeding mouse model of Alzheimer’s disease pathology},
  author={A Ahnaou and Diederik Moechars and Luc Raeymaekers and Renee Biermans and Nikolay V Manyakov and Astrid Bottelbergs and Cindy Wintmolders and Kristof van Kolen and Tom van de Casteele and John A. Kemp and Wilhelmus H. Drinkenburg},
  booktitle={Scientific Reports},
  year={2017}
}
Synaptic dysfunction and disconnectivity are core deficits in Alzheimer’s disease (AD), preceding clear changes in histopathology and cognitive functioning. Here, the early and late effects of tau pathology induction on functional network connectivity were investigated in P301L mice. Multichannel EEG oscillations were used to compute (1) coherent activity between the prefrontal cortex (PFC) and hippocampus (HPC) CA1-CA3 networks; (2) phase-amplitude cross frequency coupling (PAC) between theta… CONTINUE READING
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