Emergence of drug-resistant populations of woodchuck hepatitis virus in woodchucks treated with the antiviral nucleoside lamivudine.

@article{Zhou1999EmergenceOD,
  title={Emergence of drug-resistant populations of woodchuck hepatitis virus in woodchucks treated with the antiviral nucleoside lamivudine.},
  author={Tianlun Zhou and Jeffry R Saputelli and Carol E Aldrich and Michel Deslauriers and Lynn D. Condreay and William S. Mason},
  journal={Antimicrobial agents and chemotherapy},
  year={1999},
  volume={43 8},
  pages={1947-54}
}
Lamivudine [(-)-beta-L-2',3'-dideoxy-3'-thiacytidine] reduces woodchuck hepatitis virus (WHV) titers in the sera of chronically infected woodchucks by inhibiting viral DNA synthesis. However, after 6 to 12 months, WHV titers begin to increase toward pretreatment levels. Three WHV variants with mutations in the active site of the DNA polymerase gene are present at this time (W. S. Mason et al., Virology 245:18-32, 1998). We have asked if these mutant viruses were responsible for the lamivudine… CONTINUE READING

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