Emergence of cytotoxic T lymphocyte escape mutations in nonpathogenic simian immunodeficiency virus infection.

@article{Kaur2001EmergenceOC,
  title={Emergence of cytotoxic T lymphocyte escape mutations in nonpathogenic simian immunodeficiency virus infection.},
  author={Amitinder Kaur and Lee Alexander and Silvija I. Staprans and Lynn Denekamp and Corrina L Hale and H M Mcclure and Mark B. Feinberg and Ronald C Desrosiers and R Paul Johnson},
  journal={European journal of immunology},
  year={2001},
  volume={31 11},
  pages={3207-17}
}
Although CTL escape has been well documented in pathogenic simian immunodeficiency virus (SIV) infection, there is no information on CTL escape in nonpathogenic SIV infection in nonhuman primate hosts like the sooty mangabeys. CTL responses and sequence variation in the SIV nef gene were evaluated in one sooty mangabey and one rhesus macaque inoculated together with the same stock of cloned SIVmac239. Each animal developed an immunodominant response to a distinct CTL epitope in Nef, aa 157-167… CONTINUE READING
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