Emergence of cognitive deficits after mild traumatic brain injury due to hyperthermia
@article{Titus2015EmergenceOC, title={Emergence of cognitive deficits after mild traumatic brain injury due to hyperthermia}, author={David J Titus and Concepci{\'o}n Furones and Coleen M Atkins and W. Dalton Dietrich}, journal={Experimental Neurology}, year={2015}, volume={263}, pages={254-262} }
35 Citations
Is temperature an important variable in recovery after mild traumatic brain injury ?
- Biology
- 2019
The pathology and behavioral problems of mTBI that are exacerbated byhyperthermia are summarized, whether hyperthermia is a variable that should be considered after concussion andmTBI is discussed and potential gender considerations are discussed.
Is temperature an important variable in recovery after mild traumatic brain injury?
- BiologyF1000Research
- 2017
The pathology and behavioral problems of mTBI that are exacerbated byHyperthermia are summarized, whether hyperthermia is a variable that should be considered after concussion andmTBI is discussed and potential gender considerations are discussed.
Mild Hyperthermia Aggravates Glucose Metabolic Consequences in Repetitive Concussion
- BiologyInternational journal of molecular sciences
- 2020
It is found that repetitive mTBI significantly decreased glucose utilization bilaterally in several cortical areas, as well as in subcortical areas, including the caudate putamen and striatum, compared to sham control animals.
Hyperthermia and Mild Traumatic Brain Injury: Effects on Inflammation and the Cerebral Vasculature.
- BiologyJournal of neurotrauma
- 2018
The effects of elevated brain temperature on altered microglia/macrophage phenotype patterns after mTBI, changes in leukocyte recruitment, and TAI are evaluated to clarify the role of temperature-sensitive neuroinflammatory processes on these consequences.
An Exploratory Report on Electrographic Changes in the Cerebral Cortex Following Mild Traumatic Brain Injury with Hyperthermia in the Rat.
- BiologyTherapeutic hypothermia and temperature management
- 2020
It is demonstrated that mild TBI did not significantly alter the occurrence of events containing increases in power between the delta, theta, alpha, and alpha frequency bands in the Sprague Dawley rat 12 weeks after injury, but when hyperthermia was induced before and after CHI, electrographic events containing a similar waveform and harmonic frequency to SWDs were observed in a subset of animals.
Early Life Stress Exacerbates Outcome after Traumatic Brain Injury.
- Psychology, BiologyJournal of neurotrauma
- 2020
The findings indicate that ELS is a risk factor for worsened outcome after TBI and results in persistent learning and memory deficits, worsened cortical pathology, and an exacerbation of the hormonal stress response.
Frontal Traumatic Brain Injury Increases Impulsive Decision Making in Rats: A Potential Role for the Inflammatory Cytokine Interleukin-12.
- Psychology, BiologyJournal of neurotrauma
- 2017
The findings suggest that tissue loss alone cannot explain the increased impulsivity observed, and that inflammatory pathways mediated by IL-12 may be a contributing factor.
Frontal Traumatic Brain Injury Increases Impulsive Decision Making in Rats: A Potential Role for the Inflammatory Cytokine Interleukin-12
- Psychology, Biology
- 2017
Both milder and severe TBI caused a significant, chronic increase in impulsive decision making, and memory function, as assessed by the Morris Water Maze, was not impaired in more mildly injured rats and only transiently impacted in thesevere TBI group.
Transient forebrain ischemia under hyperthermic condition accelerates memory impairment and neuronal death in the gerbil hippocampus by increasing NMDAR1 expression
- BiologyMolecular medicine reports
- 2021
Overall, accelerated tFI-induced neuronal death under hyperthermia may be closely associated with altered NMDAR1 expression compared with that under normothermia.
Therapeutic hypothermia and targeted temperature management in traumatic brain injury: Clinical challenges for successful translation
- Biology, MedicineBrain Research
- 2016
79 References
Mild hyperthermia worsens the neuropathological damage associated with mild traumatic brain injury in rats.
- BiologyJournal of neurotrauma
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It is demonstrated that relatively mild elevations in temperature associated with peri-traumatic events may affect the long-term functional consequences of mTBI, and precautions should be introduced to target this important physiological variable.
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Continuous consumption of ethanol before and after TBI attenuated TBI-induced hyperthermia and deficits in spatial learning, and the results suggest that this ethanol regimen may be neuroprotective.
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External monitoring of temporalis muscle temperature can provide a reliable indirect measure of brain temperature in the course of experimental brain injury and indicated that brain injury itself does not influence brain temperature, anesthesia alone decreases brain temperature to levels producing cerebral protection in this model.
Development of Posttraumatic Hyperthermia after Traumatic Brain Injury in Rats is Associated with Increased Periventricular Inflammation
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The data suggest that PTH and the alteration in CR of temperature may be due, in part, to acute reactive astrocytosis and inflammation in hypothalamic centers responsible for both thermoregulation and CR.
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Delayed posttraumatic brain hyperthermia worsens outcome after fluid percussion brain injury: a light and electron microscopic study in rats.
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The experimental results indicate that posttraumatic brain hyperthermia might increase morbidity and mortality in patients with head injury by aggravating axonal and microvascular damage.
Detrimental Effects of Systemic Hyperthermia on Locomotor Function and Histopathological Outcome after Traumatic Spinal Cord Injury in the Rat
- MedicineNeurosurgery
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These data suggest that complications of SCI (e.g., fever, infection) leading to an elevation of systemic temperature may add to the severity of secondary injury associated with traumatic SCI and significantly affect neurological outcome.
Importance of Posttraumatic Hypothermia and Hyperthermia on the Inflammatory Response after Fluid Percussion Brain Injury: Biochemical and Immunocytochemical Studies
- Biology, MedicineJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
- 2000
Temperature-dependent alterations in PMNL accumulation appear to be a potential mechanism by which posttraumatic temperature manipulations may influence traumatic outcome.
Repeated mild traumatic brain injury: mechanisms of cerebral vulnerability.
- Biology, PsychologyJournal of neurotrauma
- 2013
Results suggest that the duration of metabolic depression reflects the time-course of vulnerability to second injury in the juvenile brain and could serve as a valuable biomarker in establishing window of vulnerability guidelines.