Emergence of androgen independence at early stages of prostate cancer progression in Nkx3.1; Pten mice.

@article{Gao2006EmergenceOA,
  title={Emergence of androgen independence at early stages of prostate cancer progression in Nkx3.1; Pten mice.},
  author={Hui Gao and Xuesong Ouyang and Whitney A. Banach-Petrosky and Michael M Shen and Cory Abate-Shen},
  journal={Cancer research},
  year={2006},
  volume={66 16},
  pages={
          7929-33
        }
}
Although androgen deprivation therapy is a widely used treatment for patients with advanced prostate cancer, it ultimately results in the emergence of a hormone-refractory disease that is invariably fatal. To provide insights into the genesis of this disease, we have employed an in vivo model to investigate how and when prostate epithelial cells can acquire the ability to survive and proliferate in the absence of androgens. In particular, we have been studying the evolution of androgen… CONTINUE READING
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