Emergence of an effective adaptive cell mediated immune response to Mycobacterium leprae is not impaired in reactive oxygen intermediate-deficient mice.

@article{Hagge2007EmergenceOA,
  title={Emergence of an effective adaptive cell mediated immune response to Mycobacterium leprae is not impaired in reactive oxygen intermediate-deficient mice.},
  author={Deanna Alisa Hagge and Vilma T. Marks and Nashone A. Ray and Marilyn A. Dietrich and Michael T. Kearney and David M. Scollard and James L. Krahenbuhl and Linda B. Adams},
  journal={FEMS immunology and medical microbiology},
  year={2007},
  volume={51 1},
  pages={92-101}
}
Cytokine-activated macrophages (MPhi) employ reactive oxygen intermediates (ROI) and reactive nitrogen intermediates (RNI) to combat pathogens. The requirement for ROI for an effective host response to experimental leprosy using mice which have a disruption in the 91-kD subunit of the NAPDH oxidase cytochrome b (phox91-/-) was examined. Mycobacterium leprae multiplication in phox91-/- foot pads (FP) was elevated early in infection but subsequently arrested similarly to control mice within a… CONTINUE READING

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