Emergence of a resistance-breaking isolate of Rice yellow mottle virus during serial inoculations is due to a single substitution in the genome-linked viral protein VPg.

@article{Hbrard2006EmergenceOA,
  title={Emergence of a resistance-breaking isolate of Rice yellow mottle virus during serial inoculations is due to a single substitution in the genome-linked viral protein VPg.},
  author={Eug{\'e}nie H{\'e}brard and Agn{\`e}s Pinel-Galzi and Anne Bersoult and Christelle Sir{\'e} and Denis Fargette},
  journal={The Journal of general virology},
  year={2006},
  volume={87 Pt 5},
  pages={1369-73}
}
The recessive gene rymv-1, responsible for the high resistance of Oryza sativa 'Gigante' to Rice yellow mottle virus (genus Sobemovirus), was overcome by the variant CI4*, which emerged after serial inoculations of the non-resistance-breaking (nRB) isolate CI4. By comparison of the full-length sequences of CI4 and CI4*, a non-synonymous mutation was identified at position 1729, localized in the putative VPg domain, and an assay was developed based on this single-nucleotide polymorphism. The… CONTINUE READING