Emergence of a new mutation and its accumulation in the topoisomerase IV gene confers high levels of resistance to fluoroquinolones in Escherichia coli isolates.

@article{Moon2010EmergenceOA,
  title={Emergence of a new mutation and its accumulation in the topoisomerase IV gene confers high levels of resistance to fluoroquinolones in Escherichia coli isolates.},
  author={Dong Chan Moon and Sung Yong Seol and Mamata Gurung and Jong Sook Jin and Chul Hee Choi and Jungmin Kim and Yoo Chul Lee and Dong Taek Cho and Je Chul Lee},
  journal={International journal of antimicrobial agents},
  year={2010},
  volume={35 1},
  pages={76-9}
}
Mutations in DNA gyrase and topoisomerase IV genes are the main mechanisms of resistance to quinolones. In this study, we determined mutations in gyrA, gyrB, parC and parE among 57 ciprofloxacin-resistant Escherichia coli isolates from a South Korean hospital and analysed the relationship between the minimal inhibitory concentrations (MICs) of fluoroquinolones and mutations in the topoisomerase IV gene. All ciprofloxacin-resistant E. coli isolates carried double mutations in gyrA and at least a… CONTINUE READING

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