Emergence of a new disease as a result of interspecific virulence gene transfer

  title={Emergence of a new disease as a result of interspecific virulence gene transfer},
  author={Timothy L. Friesen and Eva Holtgrewe Stukenbrock and Zhaohui Liu and Steven W. Meinhardt and Hua Ling and Justin D. Faris and Jack B. Rasmussen and Peter S. Solomon and Bruce Alan McDonald and Richard P. Oliver},
  journal={Nature Genetics},
New diseases of humans, animals and plants emerge regularly. Enhanced virulence on a new host can be facilitated by the acquisition of novel virulence factors. Interspecific gene transfer is known to be a source of such virulence factors in bacterial pathogens (often manifested as pathogenicity islands in the recipient organism) and it has been speculated that interspecific transfer of virulence factors may occur in fungal pathogens. Until now, no direct support has been available for this… 

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Evidence is given of a new disease emerging not because of interspecies or interpopulation transfer of pathogens but because of the interspecific transfer of a toxin gene that changed a previously benign microorganism into an important pathogen.

The evolution of virulence and pathogenicity in plant pathogen populations.

Evidence from viruses and cellular pathogens, mostly fungi and oomycetes, which differ widely in genomic complexity and in parasitism is compared to establish the generality of hypotheses on pathogenicity and virulence evolution.

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This work briefly summarizes current knowledge of these virulence factors from several fungal species in terms of function, phylogenetic distribution, sequence variation, and genomic location, and addresses issues that are relevant to the evolution of virulence in fungi toward plants.

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Evidence from viruses and cellular pathogens, mostly fungi and oomycetes, which differ widely in genomic complexity and in parasitism is compared to establish the generality of hypotheses on pathogenicity and virulence evolution.

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Data suggest HGT has played a role in shaping how fungi and oomycetes colonize plant hosts, and the majority of the HGTs identified are associated with invading, degrading, and manipulating the host.

Horizontal gene transfer allowed the emergence of broad host range entomopathogens

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The genomic organization of plant pathogenicity in Fusarium species.




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It is demonstrated that a single gene encodes the production of a host-selective toxin and that transformation of this gene into a non-toxin-producing isolate of P. tritici-repentis leads to both toxin production and pathogenicity.

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Role of Horizontal Gene Transfer in the Evolution of Fungi.

Fungi are well suited as model systems in which to study the mechanisms and consequences of HGT in eukaryotic organisms because they address the phenomenon in an experimental setting.

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Transposons in filamentous fungi—facts and perspectives

  • F. KempkenU. Kück
  • Biology
    BioEssays : news and reviews in molecular, cellular and developmental biology
  • 1998
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Conidial anastomosis tubes in filamentous fungi.

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Chromosomal location of a gene conditioning insensitivity in wheat to a necrosis-inducing culture filtrate from Pyrenophora tritici-repentis

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