Emergence of a mutL mutation causing multilocus sequence typing-pulsed-field gel electrophoresis discrepancy among Pseudomonas aeruginosa isolates from a cystic fibrosis patient.

@article{GarcaCastillo2012EmergenceOA,
  title={Emergence of a mutL mutation causing multilocus sequence typing-pulsed-field gel electrophoresis discrepancy among Pseudomonas aeruginosa isolates from a cystic fibrosis patient.},
  author={Mar{\'i}a Garc{\'i}a-Castillo and Luis M{\'a}iz and M C Morosini and Mercedes Rodr{\'i}guez-Ba{\~n}os and Lucrecia Su{\'a}rez and Ana Fern{\'a}ndez-Olmos and Fernando Baquero and Rafael Cant{\'o}n and Rosa Del Campo},
  journal={Journal of clinical microbiology},
  year={2012},
  volume={50 5},
  pages={1777-8}
}
A multilocus sequence type (MLST) shift (from ST242 to ST996) was detected in Pseudomonas aeruginosa isolates with a uniform pulsed-field gel electrophoresis (PFGE) pattern obtained from a chronically colonized patient. MLST mutational change involved the mutL gene with the consequent emergence of a hypermutable phenotype. This observation challenges the required neutrality of mutL as an appropriate marker in MLST and alerts researchers to the limitations of MLST-only-based population studies… CONTINUE READING
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