Emergence of Oseltamivir-Resistant H7N9 Influenza Viruses in Immunosuppressed Cynomolgus Macaques.

@article{Kiso2017EmergenceOO,
  title={Emergence of Oseltamivir-Resistant H7N9 Influenza Viruses in Immunosuppressed Cynomolgus Macaques.},
  author={Maki Kiso and Kiyoko Iwatsuki-Horimoto and Seiya Yamayoshi and Ryuta Uraki and Mutsumi Bunkyo-ku Ito and Noriko Nakajima and Shinya Yamada and Masaki Imai and Eiryo Kawakami and Yuriko Tomita and Satoshi Fukuyama and Yasushi Itoh and Kazumasa Ogasawara and Tiago J. S. Lopes and Tokiko Watanabe and Louise H. Moncla and Hideki Hasegawa and Thomas C Friedrich and Gabriele Neumann and Yoshihiro Kawaoka},
  journal={The Journal of infectious diseases},
  year={2017},
  volume={216 5},
  pages={
          582-593
        }
}
Antiviral compounds (eg, the neuraminidase inhibitor oseltamivir) are invaluable for the treatment of individuals infected with influenza A viruses of the H7N9 subtype (A[H7N9]), which have infected and killed hundreds of persons. However, oseltamivir treatment often leads to the emergence of resistant viruses in immunocompromised individuals. To better understand the emergence and properties of oseltamivir-resistant A(H7N9) viruses in immunosuppressed individuals, we infected immunosuppressed… CONTINUE READING
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