Emergence of KPC-2 and KPC-3 in carbapenem-resistant Klebsiella pneumoniae strains in an Israeli hospital.

@article{Leavitt2007EmergenceOK,
  title={Emergence of KPC-2 and KPC-3 in carbapenem-resistant Klebsiella pneumoniae strains in an Israeli hospital.},
  author={Azita Leavitt and Shiri Navon-Venezia and Inna Chmelnitsky and Mitchell James Schwaber and Yehuda Carmeli},
  journal={Antimicrobial agents and chemotherapy},
  year={2007},
  volume={51 8},
  pages={3026-9}
}
Carbapenem resistance due to KPC has rarely been observed outside the United States. We noticed a sharp increase in carbapenem-resistant Klebsiella pneumoniae strains possessing KPC in Tel Aviv Medical Center from 2004 to 2006. Sixty percent of the isolates belonged to a single clone susceptible only to gentamicin and colistin and carried the bla(KPC-3) gene, while almost all other clones carried the bla(KPC-2) gene. This rapid dissemination of KPC outside the United States is worrisome. 
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