Emergence of Drug Resistance Is Associated with an Increased Risk of Death among Patients First Starting HAART

@article{Hogg2006EmergenceOD,
  title={Emergence of Drug Resistance Is Associated with an Increased Risk of Death among Patients First Starting HAART},
  author={Robert S Hogg and David R. Bangsberg and Viviane D Lima and Chris S Alexander and Simon Joseph Bonner and Benita Yip and Evan Wood and Winnie W. Y Dong and Julio S. G. Montaner and P. Richard Harrigan},
  journal={PLoS Medicine},
  year={2006},
  volume={3},
  pages={863 - 868}
}
BACKGROUND The impact of the emergence of drug-resistance mutations on mortality is not well characterized in antiretroviral-naïve patients first starting highly active antiretroviral therapy (HAART). Patients may be able to sustain immunologic function with resistant virus, and there is limited evidence that reduced sensitivity to antiretrovirals leads to rapid disease progression or death. We undertook the present analysis to characterize the determinants of mortality in a prospective cohort… CONTINUE READING

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