Emergence of DNA Polymerase ε Antimutators That Escape Error-Induced Extinction in Yeast

  title={Emergence of DNA Polymerase ε Antimutators That Escape Error-Induced Extinction in Yeast},
  author={Lindsey N Williams and A. Herr and B. Preston},
  pages={751 - 770}
  • Lindsey N Williams, A. Herr, B. Preston
  • Published 2013
  • Biology, Medicine
  • Genetics
  • DNA polymerases (Pols) ε and δ perform the bulk of yeast leading- and lagging-strand DNA synthesis. Both Pols possess intrinsic proofreading exonucleases that edit errors during polymerization. Rare errors that elude proofreading are extended into duplex DNA and excised by the mismatch repair (MMR) system. Strains that lack Pol proofreading or MMR exhibit a 10- to 100-fold increase in spontaneous mutation rate (mutator phenotype), and inactivation of both Pol δ proofreading (pol3-01) and MMR is… CONTINUE READING
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