Emergence of CD8+ T cells expressing NK cell receptors in influenza A virus-infected mice.

Abstract

Both innate and adaptive immune responses play an important role in the recovery of the host from viral infections. In the present report, a subset of cells coexpressing CD8 and NKR-P1C (NK1.1) was found in the lungs of mice infected with influenza A virus. These cells were detected at low numbers in the lungs of uninfected mice, but represented up to 10% of the total CD8(+) T cell population at day 10 postinfection. Almost all of the CD8(+)NK1.1(+) cells were CD8alphabeta(+)CD3(+)TCRalphabeta(+) and a proportion of these cells also expressed the NK cell-associated Ly49 receptors. Interestingly, up to 30% of these cells were virus-specific T cells as determined by MHC class I tetramer staining and by intracellular staining of IFN-gamma after viral peptide stimulation. Moreover, these cells were distinct from conventional NKT cells as they were also found at increased numbers in influenza-infected CD1(-/-) mice. These results demonstrate that a significant proportion of CD8(+) T cells acquire NK1.1 and other NK cell-associated molecules, and suggests that these receptors may possibly regulate CD8(+) T cell effector functions during viral infection.

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@article{Kambayashi2000EmergenceOC, title={Emergence of CD8+ T cells expressing NK cell receptors in influenza A virus-infected mice.}, author={T Kambayashi and E Assarsson and J Micha{\"{e}lsson and P Berglund and A D Diehl and B J Chambers and H G Ljunggren}, journal={Journal of immunology}, year={2000}, volume={165 9}, pages={4964-9} }