Emergence and transmission of influenza A viruses resistant to amantadine and rimantadine.

@article{Hayden1992EmergenceAT,
  title={Emergence and transmission of influenza A viruses resistant to amantadine and rimantadine.},
  author={Frederick G. Hayden and Alan J. Hay},
  journal={Current topics in microbiology and immunology},
  year={1992},
  volume={176},
  pages={119-30}
}
Amantadine- and rimantadine-resistant viruses have been recovered from approximately 30% of patients treated for acute H3N2 subtype influenza and less often from their close contacts receiving drug prophylaxis. The limited data suggest that resistant viruses can emerge rapidly during drug therapy, as early as 2-3 days into treatment. These viruses retain their resistance phenotype during multiple passages in the laboratory and appear to be genetically stable in this regard. Studies in families… CONTINUE READING