Emergence and takeover of YMDD motif mutant hepatitis B virus during long-term lamivudine therapy and re-takeover by wild type after cessation of therapy.

Abstract

Treatment of hepatitis B virus (HBV) with lamivudine is effective in suppressing virus replication and results in reduced inflammatory activity. However, the emergence of lamivudine-resistant mutant virus, with amino acid substitution in the YMDD motif of DNA polymerase, has been reported. We report the emergence and takeover of YMDD mutant and re-takeover… (More)

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Cite this paper

@article{Chayama1998EmergenceAT, title={Emergence and takeover of YMDD motif mutant hepatitis B virus during long-term lamivudine therapy and re-takeover by wild type after cessation of therapy.}, author={Kazuaki Chayama and Yuka Suzuki and Maiko Kobayashi and Akihito Tsubota and Makoto Hashimoto and Yutaka Miyano and Haruki Koike and Isao Koida and Yasuji Arase and Shinji Saitoh and Naoya Murashima and Katsuhisa Ikeda and Hiromitsu Kumada}, journal={Hepatology}, year={1998}, volume={27 6}, pages={1711-6} }