Emergence and selection of HBV variants in an anti-HBe positive patient persistently infected with quasi-species.

@article{Alexopoulou1997EmergenceAS,
  title={Emergence and selection of HBV variants in an anti-HBe positive patient persistently infected with quasi-species.},
  author={A Alexopoulou and Peter Karayiannis and Stephanos J. Hadziyannis and Naoto Aiba and Howard Thomas},
  journal={Journal of hepatology},
  year={1997},
  volume={26 4},
  pages={748-53}
}
BACKGROUND/AIMS Infection with the hepatitis B e antigen (HBeAg) negative variant of hepatitis B virus (HBV) causes chronic liver disease characterised by occasional acute exacerbations. This virus exhibits a high prevalence of mutations in the core region. Our aim was to study the changes in the pre-core/core region of the virus in relation to exacerbations of the disease. METHODS/RESULTS We performed direct sequencing on DNA amplified from 7 sequential sera taken over a 5-year period from a… CONTINUE READING