Emergence and rapid spread of a new severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) lineage with multiple spike mutations in South Africa

@inproceedings{Tegally2020EmergenceAR,
  title={Emergence and rapid spread of a new severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) lineage with multiple spike mutations in South Africa},
  author={Houriiyah Tegally and Eduan Wilkinson and Marta Giovanetti and Arash Iranzadeh and Vagner Fonseca and Jennifer Giandhari and Deelan Doolabh and Sureshnee Pillay and Emmanuel James San and Nokukhanya Msomi and Koleka P. Mlisana and Anne von Gottberg and Sibongile Walaza and Mohamed G.I.M. Allam and Arshad Ismail and Thabo Mohale and Allison J Glass and Susan Engelbrecht and Gert van Zyl and Wolfgang Preiser and Franceso Petruccione and Alex Sigal and Diana Ruth Hardie and Gert Marais and Marvin Hsiao and Stephen N J Korsman and Mary-Ann Davies and Lynn Tyers and Innocent Mudau and Denis York and Caroline Maslo and Dominique Goedhals and Shareef Abrahams and Oluwakemi Laguda-Akingba and Arghavan Alisoltani-Dehkordi and Adam Godzik and Constantinos Kurt Wibmer and B Trevor Sewell and Jos{\'e} Lourenço and Lu{\'i}z Carlos J{\'u}nior Alc{\^a}ntara and Sergei L. Kosakovsky Pond and Steven Weaver and D. Martin},
  booktitle={medRxiv},
  year={2020}
}
Continued uncontrolled transmission of the severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) in many parts of the world is creating the conditions for significant virus evolution. Here, we describe a new SARS-CoV-2 lineage (501Y.V2) characterised by eight lineage-defining mutations in the spike protein, including three at important residues in the receptor-binding domain (K417N, E484K and N501Y) that may have functional significance. This lineage emerged in South Africa after… Expand
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