Emergence and molecular characterisation of non-toxigenic tox gene-bearing Corynebacterium diphtheriae biovar mitis in the United Kingdom, 2003-2012.

@article{Zakikhany2014EmergenceAM,
  title={Emergence and molecular characterisation of non-toxigenic tox gene-bearing Corynebacterium diphtheriae biovar mitis in the United Kingdom, 2003-2012.},
  author={Katherina Zakikhany and Shona E Neal and Androulla Efstratiou},
  journal={Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin},
  year={2014},
  volume={19 22}
}
Non-toxigenic Corynebacterium diphtheriae have become increasingly recognised as emerging pathogens across Europe causing severe invasive disease. A subset of non-toxigenic C. diphtheriae are ‘non-toxigenic tox gene-bearing’ (NTTB) strains; these strains are genotypically toxpositive, but do not express the protein. The circulation of NTTB strains was first observed during the 1990s upsurge of diphtheria in Eastern Europe but has not been reported in other European countries. Circulation of… CONTINUE READING

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