Emergence and disappearance of an immune molecule, an antimicrobial lectin, in basal metazoa. A tachylectin-related protein in the sponge Suberites domuncula.

@article{Schrder2003EmergenceAD,
  title={Emergence and disappearance of an immune molecule, an antimicrobial lectin, in basal metazoa. A tachylectin-related protein in the sponge Suberites domuncula.},
  author={Heinz C. Schr{\"o}der and Hiroshi Ushijima and Anatoli Krasko and V. Gamulin and Narsinh L. Thakur and Barbel Diehl-Seifert and Isabel M. M{\"u}ller and Werner E. G. M{\"u}ller},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 35},
  pages={32810-7}
}
Sponges (phylum Porifera) represent the evolutionarily oldest metazoans that comprise already a complex immune system and are related to the crown taxa of the protostomians and the deuterostomians. Here, we demonstrate the existence of a tachylectin-related protein in the demosponge Suberites domuncula, termed Suberites lectin. The MAPK pathway was activated in response to lipopolysaccharide treatment of the three-dimensional cell aggregates, the primmorphs; this process was abolished by the… CONTINUE READING

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