Emergence and Transmission Pathways of Rapidly Evolving Evolutionary Branch C4a Strains of Human Enterovirus 71 in the Central Plain of China

@inproceedings{Zhang2011EmergenceAT,
  title={Emergence and Transmission Pathways of Rapidly Evolving Evolutionary Branch C4a Strains of Human Enterovirus 71 in the Central Plain of China},
  author={Yong Zhang and Jitao Wang and Wanshen Guo and Haiyan Wang and Shuang-li Zhu and Dongyan Wang and Ruyin Bai and Xingle Li and Dongmei Yan and Huiling Wang and Yan Zhang and Zhen Bing Zhu and Xiaojuan Tan and Hongqiu An and Aiqiang Xu and Wenbo Xu},
  booktitle={PloS one},
  year={2011}
}
BACKGROUND Large-scale outbreaks of hand, foot, and mouth disease (HFMD) occurred repeatedly in the Central Plain of China (Shandong, Anhui, and Henan provinces) from 2007 until now. These epidemics have increased in size and severity each year and are a major public health concern in mainland China. PRINCIPAL FINDINGS Phylogenetic analysis was performed and a Bayesian Markov chain Monte Carlo tree was constructed based on the complete VP1 sequences of HEV71 isolates. These analyses showed… CONTINUE READING
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