Emergence and Genetic Variation of Neuraminidase Stalk Deletions in Avian Influenza Viruses

@inproceedings{Li2011EmergenceAG,
  title={Emergence and Genetic Variation of Neuraminidase Stalk Deletions in Avian Influenza Viruses},
  author={Jinling Li and Heinrich zu Dohna and Carol J Cardona and Joshua O. Miller and Tim E. Carpenter},
  booktitle={PloS one},
  year={2011}
}
When avian influenza viruses (AIVs) are transmitted from their reservoir hosts (wild waterfowl and shorebirds) to domestic bird species, they undergo genetic changes that have been linked to higher virulence and broader host range. Common genetic AIV modifications in viral proteins of poultry isolates are deletions in the stalk region of the neuraminidase (NA) and additions of glycosylation sites on the hemagglutinin (HA). Even though these NA deletion mutations occur in several AIV subtypes… CONTINUE READING

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